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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSP90AB1 All Species: 54.55
Human Site: T459 Identified Species: 92.31
UniProt: P08238 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08238 NP_031381.2 724 83264 T459 S E L L R Y H T S Q S G D E M
Chimpanzee Pan troglodytes A5A6K9 733 84754 T468 S E L L R Y Y T S A S G D E M
Rhesus Macaque Macaca mulatta XP_001098520 724 83571 T459 S E L L R Y H T S Q S G D E M
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P11499 724 83307 T459 S E L L R Y H T S Q S G D E M
Rat Rattus norvegicus P34058 724 83263 T459 S E L L R Y H T S Q S G D E M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518700 789 90657 T551 S E L L R Y H T S Q S G D E M
Chicken Gallus gallus Q04619 725 83409 T460 S E L L R Y H T S Q S G D E M
Frog Xenopus laevis NP_001086624 722 82939 T457 S E L L R Y H T S Q T G D E M
Zebra Danio Brachydanio rerio O57521 725 83339 S458 S E L L R Y Q S S Q S G D E M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P02828 717 81847 T452 A D F L R F H T S A S G D D F
Honey Bee Apis mellifera XP_395168 718 82735 T455 S D L L R Y H T S S S G D E V
Nematode Worm Caenorhab. elegans Q18688 702 80265 S437 L S D F L R Y S T S A G D E P
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P27323 700 80617 S439 A D L L R Y H S T K S G D E M
Baker's Yeast Sacchar. cerevisiae P02829 709 81388 S447 A K L L R Y N S T K S V D E L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86 95.1 N.A. N.A. 99.1 99.5 N.A. 86.8 94.7 92.4 91.4 N.A. 78.4 81.3 75.4 N.A.
Protein Similarity: 100 93.4 96.1 N.A. N.A. 99.5 99.8 N.A. 87.5 97.7 96.6 97 N.A. 88.5 89.9 86.8 N.A.
P-Site Identity: 100 86.6 100 N.A. N.A. 100 100 N.A. 100 100 93.3 86.6 N.A. 53.3 80 20 N.A.
P-Site Similarity: 100 93.3 100 N.A. N.A. 100 100 N.A. 100 100 100 93.3 N.A. 80 93.3 46.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 69.6 61.4 N.A.
Protein Similarity: N.A. N.A. N.A. 83.8 78.3 N.A.
P-Site Identity: N.A. N.A. N.A. 66.6 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 100 93.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 22 0 0 0 0 0 0 0 0 15 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 22 8 0 0 0 0 0 0 0 0 0 100 8 0 % D
% Glu: 0 65 0 0 0 0 0 0 0 0 0 0 0 93 0 % E
% Phe: 0 0 8 8 0 8 0 0 0 0 0 0 0 0 8 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 93 0 0 0 % G
% His: 0 0 0 0 0 0 72 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 8 0 0 0 0 0 0 0 15 0 0 0 0 0 % K
% Leu: 8 0 86 93 8 0 0 0 0 0 0 0 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 72 % M
% Asn: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % P
% Gln: 0 0 0 0 0 0 8 0 0 58 0 0 0 0 0 % Q
% Arg: 0 0 0 0 93 8 0 0 0 0 0 0 0 0 0 % R
% Ser: 72 8 0 0 0 0 0 29 79 15 86 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 72 22 0 8 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 86 15 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _